For more than 60 years, Charles River has been helping our global partners accelerate drug discovery and development by providing them with high-quality research models and preclinical and clinical support services. Our offerings span the entire drug development process, from discovery through market approval, providing our clients a seamless partnership throughout.
From the global standardization of our research models, to the high standards we set for our professional team and our state-of-the-art facilities and technologies, we can customize our products and services to meet customer’s specific research needs. With facilities around the world, Charles River is the ideal partner for moving a compound through development in a rational, cost-effective and timely manner.
- Founded: 1947
- Headquarters: Wilmington, Mass.
- Employees: ~7,000 worldwide
- Revenue: $1.14 billion in FY2011
- Ownership: Publicly traded
- Global presence: More than 60 facilities in 15 countries
- Customers: Leading pharmaceutical, biotechnology, government, and academic organizations around the world
- Service areas: Basic research; discovery; safety and efficacy; clinical support and process manufacturing
Our Global Customers
With more than 60 facilities in 15 countries, Charles River partners with leading pharmaceutical, biotechnology, government, and academic organizations around the world to provide products and services that span all stages of drug discovery and development. Our team of experts understands, and ultimately can help our customers comply with, complex and varying international scientific regulations. Our offerings are continually expanding based on the changing needs of our customers, and our portfolio reaches from the discovery of new compounds and preclinical pharmacological and safety studies to clinical trials support.
At Charles River, core to our values has always been the highest quality in service, science, and regulatory support. We have a deep commitment to both the welfare and humane care of the research models that we breed and care for, and we work in partnership with the USDA to ensure the humane treatment of all our animals. We have fostered a culture of caring within our facilities around the globe to establish ourselves as a worldwide leader in the compassionate care of research models. As part of our commitment, we are continually seeking innovative ways to provide effective testing without relying on traditional research models. To learn more, visit our Humane Care Initiative page.
Founded in 1947, Charles River was a pioneer in the production of research models for biomedical research. Since then, continued to launch new businesses and grow existing businesses, an evolution brought on by the ever-expanding needs of our customers. To learn more about the history of Charles River, visit our History page.
The drug research and development process is highly complex, lengthy and expensive, yet essential for delivering safe and effective therapies to patients. Even though the process is reasonably well-defined, drug development programs for any two products are fundamentally different for each product, as the exact testing and submission requirements are shaped by many unique factors. To help our customers navigate this process, Charles River offers a wide range of products and services that span the entire drug discovery and development continuum and can be tailored to specific research conditions. Our portfolio covers five distinct phases of drug research and development:
- Basic Research
Charles River produces a variety of research model strains, including disease-specific and preconditioned models, for basic research and beyond. With more than six decades of experience, we have developed unmatched expertise in veterinary medicine and science. Our diagnostic testing and genetic monitoring services allow our customers to have the confidence that they are working with the exact models they need for their program. Our portfolio has also expanded to encompass not only the breeding and welfare of research models, but all of the scientific services, consulting, and staffing needs required to support quality in vivo research programs. To learn more, visit our Basic Research page.
Charles River provides discovery services that help customers screen, rank, and identify lead compounds that have the greatest potential for development in an efficient, accurate, and reliable manner. With extensive research model, pharmacology, and toxicology experience, Charles River serves as an extension of our customers’ internal resources to develop customized programs. To learn more, visit our Discovery page.
- Safety and Efficacy
Charles River offers a full range of in vivo and in vitro safety and efficacy testing services that comply with global regulatory guidelines. Our scientific, program management, and regulatory expertise help our customers cost-effectively produce evidence of a compound’s biological activity and safety before moving to the clinical phase. Our customers also have access to our high-quality research models and related services, process manufacturing support, and laboratory services, as well as scientific consultants and regulatory advisors who can help interpret preclinical data and assist in the design of initial-stage clinical protocols. To learn more, visit our Safety Assessment page.
- Clinical Trial Support
Charles River provides both early- and late-phase clinical support services. As clinical trials begin, further in vitro and in vivo nonclinical studies performed within our global network of facilities provide additional information to support continuation of clinical trials. As clinical trials move to Phase II, III, and IV, we offer a wide range of laboratory services, specialty toxicology programs, process manufacturing testing and regulatory advisory personnel to bring new chemical compounds into the marketplace. To learn more, visit our Clinical Trials Support page.
- Process Manufacturing
Charles River provides consulting services for the optimization of the product manufacturing process, starting from the small amount synthesized at the laboratory bench to large-scale manufacturing. We help our customers establish the physiochemical properties of a compound, best production practices, and process controls needed to efficiently and cost-effectively bring a compound to market. To learn more, visit our Process Manufacturing Support page.