New therapies to promote bone healing or treat osteoporosis, arthritis and other skeletal diseases require a comprehensive preclinical assessment of bone and cartilage. Bone endpoints can be incorporated into toxicology programs to fully evaluate test articles that have an intended effect on bone or to determine effects of test articles that have secondary, indirect or adverse effects.
Charles River offers services in the area of bone/skeletal research that combine established discovery and preclinical program development expertise with a host of novel bone research technologies that provide highly specialized evaluations of bone disease and bone quality. Our skeletal research scientists can assess the effect of a drug in vivo or ex vivo on bone at toxicological and pharmacological doses and facilitate the interpretation of study findings to help you better design clinical trials.
Bone Research Services
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In this article, Charles River Senior Scientific Director Susan Y. Smith discusses the skeleton’s function in human physiology. "We lose weight: we lose bone; we build muscle: we build bone; we become diabetic: bones become fragile," wrote Smith. "Bone fragility and treating the consequences of fracture is a major public health concern costing millions of annual tax dollars, underscoring the need to ensure that nutraceuticals and pharmaceuticals are safe or beneficial for the skeleton."
The Charles River Animal Welfare department has made recent strides in further integrating the 3Rs into our operations. Charles River representatives are acting as ambassadors within the industry to elevate the importance of animal welfare in laboratory animal research
May 28–Jun 01
The International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) are excited to sponsor the second joint scientific meeting by the two organizations.
May 27–May 29
Charles River and the René Remie Surgical Skills Centre (RRSSC) have joined their expertise and are pleased to offer a 3-day surgery training course. Held at the RRSSC in the Netherlands, this training is designed to be very practical and combines lectures with hands-on exercises, ensuring you receive the most comprehensive training experience. This course is recommended for simple procedures only (e.g., simple exeresis, simple catheterizations such as jugular vein or femoral vein, simple ALZET pump implantation, ECG radiotelemetry).
This position is responsible for managing international aspects of US Federal income tax compliance; assisting with international tax planning, including identification of planning opportunities, designing and implementing plans, and transfer pricing process; overseeing quarterly ETR forecast process; and participating in the tax provision process, including assessment of tax risks, documentation of key positions, and review of non-US tax provision submissions.
This position is responsible for serving as a as a study director (SD), project scientist (PS) and/or principal investigator (PI) in the direction and execution of assigned studies in compliance with GLP regulations as they apply to the conduct of nonclinical research; coordinating all phases of the study planning process with appropriate departments; generating high-quality project plans, protocols, amendments and reports appropriate for assigned studies; reviewing, interpreting, integrating and presenting data on assigned studies; and functioning as contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting.
Charles River Laboratories, Inc.