Crl:NIH-Lyst bg-JFoxn1nuBtk xid
ORIGINMost commonly called the NIH-III, it was developed at NIH. In addition to the nude gene, which results in the absence of thymus and T-cell function, this mouse has two other mutations important in regulating the function of the immune system. These are designated as x-linked immune defect (xid) and beige (bg). The xid mutation affects the maturation of T-independent B lymphocytes. It has been demonstrated that bg homozygotes have defective natural killer (NK) cells that are cytotoxic in vitro to tumor cells. However, the extent of the T-independent B lymphocyte and NK cell deficiencies in the NIH-III have not been established.
STRAIN CODE 201 (HOMOZYGOUS),202 (HETEROZYGOUS*)*Heterozygous animals are not immunodeficient and are haired.
COAT COLOR Hairless, light to dark gray pigmented skin
RESEARCH APPLICATIONtumor biology and xenograft research
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Our study, presented at the 2013 Experimental Biology Conference, focuses on the phenotype and genotype comparison for C57BL/6N substrains contributing to the International Mouse Phenotyping Consortium (IMPC).
Clinical pathology data can assist you in selecting the most appropriate model for your study and can provide important information on the physiology and health of your research animals.
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